There will be no trains on the "vast majority" of rail services on two upcoming days, according to Govia Thameslink.
The company - which operates all Thameslink, Great Northern and Southern services - confirmed that train strikes will affect trains from Friday (September 29) until next Thursday (October 5).
No trains will run across the majority of the company's network on both Saturday (September 30) and next Wednesday (October 4), while fewer trains are expected on both Friday this week and next Friday.
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The first services of the day are set to begin later on both Sunday (October 1) and next Thursday (October 5), due to the ASLEF union's industrial action.
An amended timetable, with fewer services is set to run on Friday (September 29), Monday (October 2), Tuesday (October 3), Thursday (October 5) and Friday (October 6).
Jenny Saunders, Govia Thameslink's customer service director, said: “We know how difficult this ongoing national industrial action is for our customers and we're really sorry for the continued inconvenience it’s causing.
"Please plan all your journeys carefully in advance, allowing plenty of extra time, and check again before you set off.”
Train times are now available on online journey planners for both Friday and Saturday, and will be available "five to seven days in advance" for affected dates.
Journeys can be checked at www.nationalrail.co.uk.
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